Emerging Manager Spotlight: Jessica Karr of Coyote Ventures

on running with the wolves, revolutionizing women’s health and wellness, and highlighting the fringes of society

Theron McCollough
8 min readAug 9, 2022
fiifi’s Emerging Manager Spotlight on Jessica Karr of Coyote Ventures

Key Takeaways:

  1. Talk about your thesis as much as possible. Closing a first fund means talking to hundreds of people with a low conversion rate and minimal feedback, but you never know who aligns with your mission and wants to invest right away.
  2. Be steadfast in your thesis and motivation. If you don’t have the conviction of a strong thesis yet, invest with others in an SPV or as an LP.
  3. Build a diverse team that highlights and complements your expertise in order to support your portfolio. By sharing their diligence and communicating their scientific convictions clearly with other investors, Coyote brings their portcos in front of other influential investors and helps secure additional capital.

Jessica Karr is the founder & general partner of Coyote Ventures, the venture capital fund she established in 2021. Coyote is unique — Jess and her team only invest in companies solving issues to improve women’s health and wellness. By investing in this historically marginalized sector, Jess aims to help improve women’s lives, better gender equality, and invest in the



Theron McCollough

Managing Director at Citizens Private Bank | VC/Tech; past Managing Director with First Republic,@SVB_Financial. founder, investor, limited partner, and banker